Please use this identifier to cite or link to this item:
|Authors: ||Nicoletti, A.*|
Lo Fermo, S.*
|Title: ||Multiple Sclerosis in the Mount Etna Region: Possible Role of Volcanogenic Trace Elements|
|Title of journal: ||PLoS one|
|Series/Report no.: ||12/8(2013)|
|Publisher: ||Public Library of Science|
|Issue Date: ||11-Dec-2013|
|Keywords: ||Mt. Etna volcano|
|Abstract: ||Background: Trace elements have been hypothesised to be involved in the pathogenesis of Multiple Sclerosis and volcanic
degassing is the major natural sources of trace elements. Both incidence of Multiple Sclerosis in Catania and volcanic activity
of Mount Etna have been significantly increased during the last 30 years. Due to prevailing trade winds direction, volcanic
gases from Etna summit craters are mostly blown towards the eastern and southern sectors of the volcano.
Objective: To evaluate the possible association between Multiple Sclerosis and exposure to volcanogenic trace elements.
Methods: We evaluated prevalence and incidence of Multiple Sclerosis in four communities (47,234 inhabitants) located in
the eastern flank and in two communities (52,210 inhabitants) located in the western flank of Mount Etna, respectively the
most and least exposed area to crater gas emissions.
Results: A higher prevalence was found in the population of the eastern flank compared to the population of the western
one (137.6/100,000 versus 94.3/100,000; p-value 0.04). We found a borderline significantly higher incidence risk during the
incidence study period (1980–2009) in the population of the eastern flank 4.6/100,000 (95% CI 3.1–5.9), compared with the
western population 3.2/100,000 (95% CI 2.4–4.2) with a RR of 1.41 (95% CI 0.97–2.05; p-value 0.06). Incidence risks have
increased over the time in both populations reaching a peak of 6.4/100,000 in the eastern flank and of 4.4/100.000 in the
western flank during 2000–2009.
Conclusion: We found a higher prevalence and incidence of Multiple Sclerosis among populations living in the eastern flank
of Mount Etna. According to our data a possible role of TE cannot be ruled out as possible co-factor in the MS pathogenesis.
However larger epidemiological study are needed to confirm this hypothesis.|
|Appears in Collections:||05.08.01. Environmental risk|
Papers Published / Papers in press
Files in This Item:
|Nicoletti et al 2013 PLOS ONE.pdf||Main article||437.88 kB||Adobe PDF||View/Open
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.